Real Madrid look to take another step toward a 15th title when they host RB Leipzig on Wednesday for the second leg of their Round-of-16 tie in the 2023-24 UEFA Champions League. Real Madrid, who have twice as many UCL championships as the next-closest team (AC Milan), went a perfect 6-0-0 during the group stage before edging RB Leipzig 1-0 in the first leg of their matchup. The Red Bulls, who were 4-0-2 in group play, aim to advance past the Round of 16 for the first time since 2019-20, when they lost to PSG in the semifinals.

Kickoff at Estadio Santiago Bernabeu is set for 3 p.m. ET. Los Blancos are -200 favorites (risk $200 to win $100) in the latest Real Madrid vs. RB Leipzig odds, while the Red Bulls are +450 underdogs. A 90-minute draw is priced at +360 and the over/under for total goals scored is 3.5. (For more soccer coverage, click here.)

Before you lock in your RB Leipzig vs. Real Madrid picks or UEFA Champions League predictions, you NEED to see what soccer bettor Jon "Buckets" Eimer has to say.

Eimer is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, he has covered the English Premier League, Serie A, the FA Cup and much more. In 2023, he was red-hot, going 248-234-12 for a profit of $2,593 for $100 bettors. That included an 86-59-5 record in the Premier League for a $3,463 profit.

Eimer knows Real Madrid enter the second leg of this tie with an eight-game unbeaten streak across all competitions during which they have recorded six wins and a pair of draws. Los Blancos have outscored their opponents 17-7 in the Champions League, with five different players converting multiple times. Leading the club is midfielder Jude Bellingham, who is tied for sixth in the competition with four goals and shares third place with three assists. 

The expert also is aware that RB Leipzig are led offensively by Lois Openda, who also has scored four times in the competition. The 24-year-old Belgian striker, who is third in the German Bundesliga with 17 goals, netted three of his four tallies in the Red Bulls' two group-stage losses to Manchester City. Slovenian forward Benjamin Sesko and Dutch midfielder Xavi Simons both have converted twice for Leipzig in the UCL.

Eimer has taken an in-depth look at the Real Madrid vs. RB Leipzig showdown and is leaning Over on the goal total. He also has locked in three CONFIDENT best bets, including two that pay plus-money, and is offering a full breakdown of this Champions League match! You ABSOLUTELY need to see his picks and analysis before making any selections of your own.

Who wins Real Madrid vs. RB Leipzig, and what are the best bets you can make? ... Join SportsLine now to see Jon Eimer's picks for RB Leipzig vs. Real Madrid, all from the expert who had a profit of almost $2,600 in 2023!