2022 NCAA Tournament UCLA vs. Saint Mary's odds, predictions: College basketball lines, picks for Saturday by top model

Two California teams will lock horns in the second round of the 2022 NCAA Tournament as No. 4 UCLA will take on No. 5 Saint Mary's. The Bruins won a nail-biter in Thursday's opener with a 57-53 victory over Akron. Meanwhile, the Gaels had little difficulty in its first-round game as it breezed by Indiana by a score of 82-53. The winner of Sunday's matchup will have a stern test in the Sweet Sixteen, facing either defending champion Baylor or a Blue Blood program in North Carolina.

Tipoff is set for 7:10 p.m. ET at Moda Center in Portland, Ore. The Bruins are three-point favorites in the latest UCLA vs. Saint Mary's odds from Caesars Sportsbook, and the Over-Under is set at 126. (Head over to our college basketball odds page for up-to-date odds on every game). 

Before you make any Saint Mary's vs. UCLA picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows that no team can match the tourney experience of the Bruins who returned the entire starting lineup that made a Final Four run last season. UCLA placed three players on the All-Pac-12 first-team in juniors Jaime Jaquez, Johnny Juzang and Tyger Campbell. The three combined for over 70 percent of UCLA's scoring in its tournament opener and they are proven March performers.

The model also knows that few teams had a better first-round performance than the Gaels, who defeated an Indiana squad by 29 points. Saint Mary's starting lineup alone outscored the entire Hoosiers squad by a 58-53 margin, and Logan Johnson led the way with 20 points. He leads the WCC in steals and he put in work on the defensive end of the court as well with three swipes of the Hoosiers.

Now, the model has broken down the UCLA vs. Saint Mary's matchup from every angle and revealed its results. We can tell you the model is leaning Over on the total, and it also says one side of the spread hits in well over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Saint Mary's vs. UCLA in their 2022 NCAA Tournament opener? And which side of the spread hits well over 60 percent of the time? ... Join SportsLine right now to find out which side of the UCLA vs. Saint Mary's spread you should be all over Saturday, all from the model on a roll on college basketball picks!