The Loyola Chicago Ramblers square off against the Ohio State Buckeyes in a first round matchup as part of the 2022 NCAA Tournament at 12:15 p.m. ET on Friday. Caesars Sportsbook lists the game as a pick'em, while the Over-Under is set at 133.5 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Loyola Chicago vs. Ohio State picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Ohio State is excellent on offense. Standout forward E.J. Liddell is one of the best players in the country, averaging 19.6 points and 7.9 rebounds per game, and the Buckeyes rank in the top 15 nationally in offensive efficiency. Ohio State is in the top 25 of the country in shooting efficiency, including 37.3 percent from 3-point range, and the Buckeyes are above-average in creating free throw attempts. Ohio State is also strong in ball security, turning the ball over on only 16.6 percent of possessions.

The model also knows Loyola Chicago is quite good on defense. The Ramblers rank in the top 25 of the country in defensive efficiency, and Loyola Chicago is disciplined and aggressive. Loyola Chicago is a fantastic defensive rebounding team, securing 76.1 percent of missed shots, and the Ramblers led the Missouri Valley in turnover creation rate at 19.7 percent. Loyola Chicago also sports a 10.0 percent block rate and a top-25 national mark in assist rate allowed.

Now, it has set its sights on Loyola Chicago vs. Ohio State. We can tell you the model is leaning over the total, and it also says one side of the spread hits in over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Loyola Chicago vs. Ohio State? And which side of the spread hits in over 60 percent of simulations? ... Join SportsLine right now to find out which side of the Loyola Chicago vs. Ohio State spread you should be all over Friday, all from the model on a roll on college basketball picks!