Daniil Medvedev can regain the World No. 1 ranking when he competes in the 2022 Miami Open, beginning Wednesday at Hard Rock Stadium in South Florida. Medvedev is the +250 (risk $100 to win $250) favorite in the 2022 Miami Open odds from Caesars Sportsbook, while 6-foot-6 German Alexander Zverev is going off at +550. The top Americans -- Taylor Fritz, Sebastian Korda and Reilly Opelka -- are all listed at +5000. 

Before you make any Miami Open picks, see the Miami Open 2022 predictions from renowned tennis handicapper Sean Calvert.

Calvert is the famed handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1. Anyone following his picks is way up.

Now, Calvert has scrutinized the latest Miami Open odds and released his coveted best bets to win it all. We can tell you he's fading both Medvedev and Zverev even though they are the top two favorites. Medvedev has never advanced past the quarterfinals in Miami, and the court conditions in South Florida are slower than he prefers. Zverev also has never won a match at the Hard Rock Stadium.

But Calvert loves two long shots, including one who would pay more than 40-1. This big server "can go deep at a nice price," Calvert says. He's sharing who it is, and all his picks, only with SportsLine members.

Who wins the 2022 Miami Open men's singles title? Which monumental long shots could take the crown? ... Join SportsLine right now to see Sean Calvert's detailed 2022 Miami Open picks and analysis, all from the renowned tennis expert who called Stan Wawrinka winning the Australia Open at 60-1!