Paris-Saint Germain has a commanding lead as it prepares to host Barcelona with a quarterfinal berth on the line in the 2020-21 UEFA Champions League on Wednesday. PSG won the first leg of the Round of 16 matchup 4-1. 

Kickoff is set for 3 p.m. ET. PSG is a 0.5-goal and +150 money-line favorite in the latest Barcelona vs. Paris-Saint Germain odds at William Hill Sportsbook, and the Over-Under for total goals scored is 3.5. 

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