Simulation Picks
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Expert Picks
I think the Cardinals are going to have issues moving the ball with their offensive-line injuries squaring off against a talented, young San Francisco front. On defense, the Cardinals are plenty capable of limiting the 49ers passing attack. Add it up and points will likely be at a premium in this game. I can't see both teams reaching 20 points, so I'm hitting the Under here.
The Cardinals haven't played well enough at any point of the season to justify this line. They've had no running game from the moment David Johnson went down, and Carson Palmer has been erratic enough with his passes that you can't trust him to carry the load and lead his team to a blowout win. The 49ers found something that works offensively last week, and having the extra time to prepare for this game should help such a young team. I expect this game to be decided by a field goal either way.