Yankees vs. Tigers odds, line, prediction: 2026 MLB picks for Monday, June 22, from proven model

The Detroit Tigers will look to win their fourth game in a row when they battle the New York Yankees in a key American League matchup on Monday night. Detroit completed a three-game sweep over the Chicago White Sox with a 5-4 10-inning win on Sunday, while New York lost two of three to the Cincinnati Reds, including a 4-1 decision on Sunday. The Yankees (46-30), who lead the AL East, are 24-15 on the road this season. The Tigers (33-44), fourth in the AL Central, are 21-16 on their home field in 2026.

First pitch from Comerica Park in Detroit is set for 6:10 p.m. ET. The teams have split each of the last 12 meetings. New York is a -124 favorite on the money line (risk $124 to win $100) in the latest Yankees vs. Tigers odds, while the over/under, is 8. 

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The model has simulated Yankees vs. Tigers 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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