Yankees vs. Tigers odds, line, prediction: 2026 MLB picks for Monday, June 22, from proven model

The Detroit Tigers will look to win their fourth game in a row when they battle the New York Yankees in a key American League matchup on Monday night. Detroit completed a three-game sweep over the Chicago White Sox with a 5-4 10-inning win on Sunday, while New York lost two of three to the Cincinnati Reds, including a 4-1 decision on Sunday. 

The Yankees (46-30), who lead the AL East, are 24-15 on the road this season. Gerrit Cole (2-1, 2.57 ERA) will make his sixth start since returning from Tommy John surgery. The Tigers (33-44), fourth in the AL Central, are 21-16 on their home field in 2026. Framber Valdez (3-5, 4.09 ERA) is on the hill for Detroit.

First pitch from Comerica Park in Detroit is set for 6:10 p.m. ET. New York is a -131 favorite on the money line (risk $131 to win $100) in the latest Yankees vs. Tigers odds, while the over/under, is 8.5.

Before making any Yankees vs. Tigers picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times and entered Week 13 of the MLB season on a sizzling 22-10 run on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!   

The model has simulated Yankees vs. Tigers 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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