Yankees vs. Red Sox odds, line, prediction: 2026 MLB picks for Wednesday's matchup from proven model

The New York Yankees will look to extend their winning streak to five games when they battle the Boston Red Sox in the second of a three-game series on Wednesday night. New York downed Boston 4-0 on Tuesday. The Yankees (14-9), who lead the American League East, are 6-4 on the road this season. The Red Sox (9-14), who have lost three of four, are 5-6 on their home field in 2026.

First pitch from Fenway Park in Boston is set for 6:45 p.m. ET. The Yankees lead the all-time series 1,277-1,075, and have won six of the last eight meetings. New York is a -142 favorite on the money line (risk $142 to win $100) in the latest Yankees vs. Red Sox odds, while the over/under, is 8. 

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The model has simulated Yankees vs. Red Sox 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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