Yankees vs. Pirates odds, prediction, time: 2026 MLB picks for Wednesday, July 22 from proven model

The New York Yankees and Pittsburgh Pirates will play a day/night doubleheader on Wednesday's MLB schedule after rain postponed Tuesday's contest. New York (56-44) took Monday's game, 8-5, and is second in the AL East, while Pittsburgh (52-49) is fourth in the NL Central but is tied for the last Wild Card spot. Former Pirate, Gerrit Cole (3-5, 3.93 ERA), will take the mound for the Yankees, countered by Mitch Keller (6-7, 5.14 ERA) of Pittsburgh.

First pitch is at 1:05 p.m. ET from Yankee Stadium in the Bronx, N.Y. The latest Pirates vs. Yankees odds list New York as the -168 favorite (risk $168 to win $100). The over/under for total runs is 9.5.
 
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