Yankees vs. Cubs odds, line, prediction: 2026 MLB picks for Friday, July 31, from proven model

The New York Yankees look to snap a two-game losing streak when they battle the Chicago Cubs in a key interleague matchup on Friday afternoon. New York is coming off a 2-1 11-inning loss to the Chicago White Sox on Thursday, while the Cubs earned a 4-2 10-inning win over the St. Louis Cardinals. The Yankees (61-48), who are second in the American League East, are 35-25 on the road this season. The Cubs (62-47), who are second in the National League Central, are 30-22 on their home field in 2026.

First pitch from Wrigley Field in Chicago is set for 2:20 p.m. ET. The Yankees lead the all-time series 27-9, but the Cubs have won three of the last four meetings. Chicago is a -140 favorite on the money line (risk $140 to win $100) in the latest Yankees vs. Cubs odds, while the over/under, is 9. Before making any Yankees vs. Cubs picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times and entered Week 19 of the MLB season on a sizzling 39-23 run on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has simulated Yankees vs. Cubs 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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