The New York Yankees look to snap a two-game losing streak when they battle the Chicago Cubs in a key interleague matchup on Friday afternoon. New York is coming off a 2-1 11-inning loss to the Chicago White Sox on Thursday, while the Cubs earned a 4-2 10-inning win over the St. Louis Cardinals. The Yankees (61-48), who are second in the American League East, are 35-25 on the road this season. The Cubs (62-47), who are second in the National League Central, are 30-22 on their home field in 2026.
First pitch from Wrigley Field in Chicago is set for 2:20 p.m. ET. Chicago is a -157 favorite on the money line (risk $157 to win $100) in the latest Yankees vs. Cubs odds, while the over/under, is 9. Before making any Yankees vs. Cubs picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.