A matchup between the two best teams in the American League will take place on Thursday as the Houston Astros (43-25) take on the New York Yankees (51-18) in the first game of a four-game series. New York is a -125 favorite (risk $125 to win $100) on the money line in the latest Yankees vs. Astros odds from Caesars Sportsbook, while the over-under for total runs scored is eight (see up-to-date odds for every game this week on our MLB odds page).

Before making any Astros vs. Yankees picks, you NEED to check out the MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 56-47 roll on top-rated MLB money-line picks through 11 weeks. Anybody who has followed it has seen profitable returns.

The model knows that Houston is a runaway leader in the AL West, holding a 10-game lead over the Rangers entering Thursday's action. Yordan Alvarez is establishing himself as one of the league's best hitters and enters this four-game series with 21 home runs, 51 RBIs and a staggering 1.064 OPS. 

The model also knows that the Yankees have an AL MVP candidate of their own in Aaron Judge. His 27 home runs lead the MLB and he also has 52 RBIs and a .302/.379/.663 slash line on the season. He's helped power the Yankees to a massive 12-game lead in the AL East over the Blue Jays. 

Now, the model has set its sights on Yankees vs. Astros. We can tell you the model is leaning Over the total, and it also says one side of the money line has ALL the value. You ABSOLUTELY need to see it before locking in any MLB picks.

So who wins Yankees vs. Astros? And which side of the money line has ALL the value? Join SportsLine here to find out, all from the model that has crushed its top-rated MLB money-line picks!