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Yankees vs. Angels odds, line, prediction: 2026 MLB picks for Thursday, April 16 from proven model

SportsLine's projection model, which is on a 35-29 roll on top-rated MLB money-line picks, has locked in its MLB predictions for the New York Yankees vs. Los Angeles Angels on Thursday

ByUpdated: Apr 16, 2026 2:03PM UTC . 2 min read

A pair of AL squads will conclude a four-game mid-week series on Thursday's MLB schedule as the New York Yankees host the Los Angeles Angels. New York (10-8) took Wednesday's contest after splitting the first two games of the series. Los Angeles (9-10) has now alternated losses with wins over its last seven outings. Max Fried (2-0, 1.93 ERA) will make the start for the Yankees, while L.A. has yet to announce a starter. The Yanks are 6-4 versus the Angels since the start of last season.

First pitch is at 1:35 p.m. ET from Yankee Stadium in New York City. The latest Angels vs. Yankees odds list New York as the -292 favorite on the money line (risk $292 to win $100). The over/under for total runs is 9.5.

Before making any Yankees vs. Angels picks or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It was a profitable 35-29 on top-rated MLB money-line picks last season. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has simulated Angels vs. Yankees 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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