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White Sox vs. Yankees odds, line, picks: Proven model reveals MLB picks for May 22, 2022 matchup

SportsLine's projection model generated selections for Sunday Night Baseball between the Chicago White Sox and the New York Yankees
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The Chicago White Sox (19-20) and the New York Yankees (29-10) square off in the second game of their doubleheader on Sunday Night Baseball with the first pitch set for 7:08 p.m. ET. New York is listed as the -170 favorite (risk $170 to win $100) at Caesars Sportsbook, while Chicago is set as the +150 underdog. The over-under for total runs expected is set at nine (see up-to-date odds for every game this week on our MLB odds page).

Before making any White Sox vs. Yankees picks, you NEED to check out the MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a profitable start to the 2022 season. It's on a 33-25 roll on top-rated MLB money-line picks through six weeks, returning over $300 for $100 players. Anyone following it has seen HUGE returns!

The model knows New York designated hitter Giancarlo Stanton is a big-time slugger with monster power in his swing. Stanton is off to a terrific start to the campaign and has been a reliable offensive outlet. The four-time All-Star leads the team in batting average (.309), RBIs (35), and hits (43). In his last outing, he went 3-for-4 with three singles. 

The model also knows Chicago shortstop Tim Anderson has great bat control with amazing speed on the field. Anderson is able to drive the ball all over the diamond consistently due to his solid hands. The 2021 All-Star ranks first on the team in batting average (.350), on-base percentage (.393), and hits (49). He's recorded 2-plus hits in three straight games. 

Now, it has set its sights on White Sox vs. Yankees. We can tell you the model is leaning Under the total, and it also says one side of the money line has ALL the value. You ABSOLUTELY need to see it before locking in any MLB picks.

So who wins White Sox vs. Yankees? And which side of the money line has ALL the value? Join SportsLine here to find out, all from the model that has crushed its top-rated MLB money-line picks!

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SportsLine Staff