White Sox vs. Guardians odds, picks: Advanced computer MLB model releases selections for Sunday matchup

The Cleveland Guardians host the Chicago White Sox in a matinee clash between division foes at 12:05 p.m. ET on Sunday. Chicago is listed as a -125 favorite (risk $125 to win $100) at Caesars Sportsbook, while the Over/Under is set at 7.5 (see up-to-date odds for every game this week on our MLB odds page). Before making any White Sox vs. Guardians picks, you NEED to check out the MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 300-260 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

The model knows the White Sox have the pitching edge behind Dylan Cease. The 26-year-old is a Cy Young candidate in the American League, sporting a 2.09 ERA this season. Cease leads the American League in striking out 11.98 batters per nine innings, and opponents have a .602 OPS against him. Cease recently had a 14-start stretch allowing one earned run or fewer, and he has a 0.93 ERA since May 29.

The model also knows the Guardians have a rock-solid offense. Cleveland leads the AL in strikeout avoidance as a team, and the Guardians are in the top four of the league in myriad categories. That includes hits, doubles, triples, batting average, and stolen bases, with above-average marks in on-base percentage, slugging percentage, OPS, and runs scored. Cleveland also has a top-five bullpen in the AL in both ERA and wins above replacement.

Now, it has set its sights on White Sox vs. Guardians. We can tell you the model is leaning over the total, and it also says one team has all the value! You ABSOLUTELY need to see it before locking in any MLB picks.

Who wins White Sox vs. Guardians? And which team has all the value on the money line? ... Join SportsLine right now to find out which side of the White Sox vs. Guardians matchup you should be all over Sunday, all from the model on a roll on MLB picks!