The Chicago White Sox meet the Chicago Cubs in an interleague matchup on Friday afternoon. First pitch from Wrigley Field in Chicago is at 2:20 p.m. ET. The White Sox are listed as -172 favorites (risk $172 to win $100) on the money line in the latest White Sox vs. Cubs odds from Caesars Sportsbook, while the over-under for total runs scored is nine (see the latest lines for every game on our MLB odds page).

Before making any Cubs vs. White Sox picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, is a profitable 140-113 on top-rated MLB money-line picks through 18 weeks in the 2021 season. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some HUGE returns!

Now, it has set its sights on Cubs vs. White Sox. We can tell you it's leaning Under, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Cubs vs. White Sox? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the White Sox vs. Cubs money line you should be all over on Friday, all from the model that is 140-113 on MLB picks in 2021!