Trail Blazers vs. 76ers prediction, odds, line, spread, start time: 2025 NBA picks, March 3 best bets from proven computer simulation model

The Philadelphia 76ers will look to sweep the two-game season series with the Portland Trail Blazers when they meet in an interconference matchup Monday night. Portland blew a double-digit lead and lost 133-129 in overtime to the Cleveland Cavaliers Sunday afternoon, while Philadelphia defeated the Golden State Warriors 126-119 Saturday. The Trail Blazers (27-34), who are fourth in the Northwest Division, are 11-20 on the road this season. The 76ers (21-38), who are third in the Atlantic Division, are 11-20 on their home court. Philadelphia center Joel Embiid (knee) has been ruled out for the rest of the season. Deandre Ayton (calf) and Jerami Grant (knee) are out for Portland.

Tipoff from Wells Fargo Center in Philadelphia is set for 7 p.m. ET. The 76ers are 2-point favorites in the latest Trail Blazers vs. 76ers odds from SportsLine consensus, while the over/under for total points scored is 229. The Sixers are at -134 on the money line (risk $134 to win $100), while Portland is at +113 (risk $100 to win $113).

Before making any Trail Blazers vs. 76ers picks, check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 20 of the 2024-25 NBA season on a sizzling 147-107 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It's also an outstanding 18-10 (64%) on top-rated spread picks this season. Anyone following at sportsbooks and on betting apps could have seen HUGE returns!

The model has simulated Trail Blazers vs. 76ers 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that hits almost 60% of the time!

So who wins Trail Blazers vs. 76ers, and  which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks!