Timberwolves vs. Spurs odds, line: Proven model reveals picks for NBA Western Conference semifinal Game 1 matchup on Monday, May 4

The sixth-seeded Minnesota Timberwolves meet the second-seeded San Antonio Spurs in Game 1 of their Western Conference semifinal matchup on Monday night. Minnesota advanced with a 110-98 win over the Denver Nuggets on Thursday, while San Antonio defeated Portland 114-95 on Tuesday. The Timberwolves (49-33), who placed third in the Northwest Division, are 24-20 on the road this season, including postseason. The Spurs (62-20), who won the Southwest Division, are 34-9 on their home court. Minnesota will be without Anthony Edwards (knee).

Tip-off from Frost Bank Center in San Antonio is set for 9:30 p.m. ET. The Spurs lead the all-time postseason series 6-2, including five of the last six games. The Spurs are a 13.5-point favorite in the latest Timberwolves vs. Spurs odds from FanDuel Sportsbook, while the over/under for total points scored is 217.5. 

Before making any Timberwolves vs. Spurs picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second full week of the 2026 NBA playoffs on a sizzling 25-9 roll (74%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Timberwolves vs. Spurs 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread hits nearly 60% of the time!

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