Tigers vs. Red Sox odds, line, prediction: 2026 MLB picks for Monday's Patriots Day matchup from proven model

The Detroit Tigers look to win their wrap-around four-game series against the Boston Red Sox when they meet on a Patriots Day matchup on Monday morning. Detroit is coming off a 6-2 win over Boston on Sunday. The Tigers (12-10), who have won two in a row, are 4-9 on the road this season. The Red Sox (8-13), who have lost two in a row, are 4-5 on their home field.

First pitch from Fenway Park in Boston is set for 11:10 a.m. ET. The Red Sox lead the all-time series 1,068-993, but the Tigers have won nine of the last 13 meetings. Boston is a -134 favorite on the money line (risk $134 to win $100) in the latest Tigers vs. Red Sox odds, while the over/under, is 8. 

Before making any Tigers vs. Red Sox picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

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The model has simulated Tigers vs. Red Sox 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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