After battling to the last day of the regular season, American League Central rivals clash when the Detroit Tigers meet the division-winning Cleveland Guardians in Game 1 of the Wild Card round on Tuesday. Cleveland had trailed Detroit by as many as 15.5 games in July before making up all the ground and winning the division by one game. The Tigers (87-75), who went just 2-8 down the stretch, are 41-40 on the road this season. The Guardians (88-74), who won seven of 10, are 45-36 on their home field in 2025.

First pitch from Progressive Field in Cleveland is set for 1:08 p.m. ET. The all-time series is tied 1,166-1,166, with Cleveland winning eight of 13 games during the regular season. Detroit is a -166 favorite on the money line (risk $166 to win $100) in the latest Tigers vs. Guardians odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 6 in the latest MLB odds. 

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The model has simulated Tigers vs. Guardians 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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