Spurs vs. Trail Blazers odds, line: Proven model reveals NBA picks for Game 5 matchup on Tuesday, April 28

The San Antonio Spurs will look to punch their tickets to the second round of the NBA playoffs 2026 when they meet the Portland Trail Blazers on Tuesday. San Antonio (62-20) lead this series, 3-1, after Victor Wembanyama's return spurred a 114-93 road victory on Sunday. No. 7 Portland (42-40) wasn't able to take advantage of temporarily stealing home-court advantage as it dropped both Games 3 and 4 at home. The Spurs won two of three matchups in the regular season.

Tip-off is at 9:30 p.m. ET from Frost Bank Center in San Antonio. The Spurs are 12-point favorites in the latest Trail Blazers vs. Spurs odds from FanDuel Sportsbook, while the over/under for total points scored is 215.5.

Before making any Spurs vs. Trail Blazers picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the first full week of the 2026 NBA playoffs on a sizzling 24-9 roll (73%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Spurs vs. Blazers 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread hits almost 60% of the time!

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