Spurs vs. Timberwolves odds, line: Proven model reveals picks for NBA Western Conference semifinal Game 6 matchup on Friday, May 15

The second-seeded San Antonio Spurs will look to close out their best-of-seven series when they face the sixth-seeded Minnesota Timberwolves in Game 6 of their Western Conference semifinal on Friday night. San Antonio cruised to a 126-97 win in Tuesday's Game 5 matchup to take a 3-2 series lead. The Spurs (62-20), who are looking to reach the conference finals for the first time since 2016-17, are 32-13 on the road this season, including playoffs. The Timberwolves (49-33), who are looking to reach the conference finals for the third time in four years, are 30-16 on their home court in 2025-26.

Tip-off from Target Center in Minneapolis is set for 9:30 p.m. ET. The Spurs lead the all-time postseason series 9-4. The Spurs are a 4.5-point favorite in the latest Spurs vs. Timberwolves odds from FanDuel Sportsbook, while the over/under for total points scored is 218.5. 

Before making any Spurs vs. Timberwolves picks, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second round of the 2026 NBA playoffs on a sizzling 26-9 roll (74%) on top-rated NBA spread picks this season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen HUGE returns!

The model has simulated Spurs vs. Timberwolves 10,000 times and the results are in. The model is going Under on the point total, and it also says one side of the spread hits nearly 60% of the time!

Who wins Spurs vs. Timberwolves, and which side of the spread hits nearly 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 26-9 roll on top-rated NBA picks!