Spurs vs. Blazers odds, line: Proven model reveals NBA picks, Game 2 bets for NBA playoff matchup on Tuesday, April 21

The 2026 NBA playoffs feature a trio of Game 2 matchups on Tuesday, including the San Antonio Spurs hosting the Portland Trail Blazers. The 2-seeded Spurs (62-20) rolled to a 111-98 victory in Game 1 to give them their 15th win over their last 17 games. No. 7 Portland (42-40) saw its three-game win streak come to an end on Sunday. San Antonio won two of three matchups in the regular season.

Tipoff is at 8 p.m. ET from the Frost Bank Center in San Antonio. The latest Spurs vs. Trail Blazers odds have San Antonio as 11.5-point favorites, while the over/under is 220.5.

Before making any Spurs vs. Blazers picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the 2026 NBA playoffs on a sizzling 23-9 roll (72%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Blazers vs. Spurs 10,000 times and the results are in. The model is going Under on the point total, and it also says one side of the spread is the better value!

Who wins Spurs vs. Blazers, and which side of the spread is the better value? ... Join SportsLine right now to find out which side of the Trail Blazers vs. Spurs spread you should be all over, all from the model on a 23-9 roll on top-rated NBA picks!