A first round 2022 NCAA Tournament matchup is set between No. 5 seed Saint Mary's and No. 12 seed Indiana at 7:20 p.m. ET on Thursday at the Moda Center at the Rose Quarter. The Gaels are 25-7 overall, while Indiana is 21-13 overall. Saint Mary's finished in second place in the West Coast Conference; Indiana was ninth in the Big Ten. 

The Gaels are favored by 2.5 points in the latest Saint Mary's vs. Indiana odds from Caesars Sportsbook, while the over-under is set at 124.5. Before you make any Indiana vs. Saint Mary's picks or predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Saint Mary's vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Saint Mary's vs. Indiana? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.