The red-hot Cincinnati Reds take on the Pittsburgh Pirates in a National League Central matchup on Wednesday afternoon. The Reds (25-25), third in the division, have won five of six. The Pirates (16-33), fifth in the Central, have dropped four of five and are just 10-14 on their home field.

First pitch from PNC Park in Pittsburgh is set for 12:35 p.m. ET. Cincinnati is a –127 favorite on the money line (risk $127 to win $100) in the latest Reds vs. Pirates odds, while the total number of runs Vegas thinks will be scored, or the over-under, is 8 in the latest MLB odds. 

Before you make any Reds vs. Pirates picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 9 of the 2025 MLB season on a 13-8 run (62%) on top-rated MLB money-line picks. Anybody following could have seen strong returns!

The model has simulated Reds vs. Pirates 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

Who wins Reds vs. Pirates, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 13-8 roll on top-rated MLB picks!