Red Sox vs. Twins odds, line, prediction: 2026 MLB picks for Wednesday afternoon from proven model

The Minnesota Twins look to complete the sweep when they battle the Boston Red Sox in the third and final game of their series on Wednesday. Minnesota is coming off a 6-0 win on Tuesday night. The Red Sox (6-11), who are fifth in the American League East, are 3-8 on the road this season. The Twins (11-7), who are first in the AL Central, have won four in a row and are 7-2 on their home field.

First pitch from Target Field in Minneapolis is set for 1:40 p.m. ET. The Red Sox lead the all-time series 997-961, but the Twins have won five of the last seven meetings. Boston is a -131 favorite on the money line (risk $131 to win $100) in the latest Red Sox vs. Twins odds, while the over/under, is 8. 

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The model has simulated Red Sox vs. Twins 10,000 times and the results are in. The model is going Under on the total, and is also says one side of the money line has ALL the value!

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