Red Sox vs. Tigers odds, line, prediction: 2026 MLB picks for Tuesday, May 5 from proven model

The Detroit Tigers will look to bounce back after a tough Monday when they host the Boston Red Sox in the second of a three-game set on Tuesday's MLB schedule. Detroit (18-18) not only lost 5-4 to Boston yesterday, but the Tigers also lost two-time Cy Young winner, Tarik Skubal, indefinitely due to elbow surgery. Skubal was scratched before Monday's scheduled start, and the Red Sox (14-21) took advantage to win their third straight series opener. Jovani Moran (0-0, 2.33 ERA) is set to make his first career start for Boston, countered by Detroit's Framber Valdez (2-1, 3.35 ERA).

First pitch is at 6:40 p.m. ET from Comerica Park in Detroit. The latest Tigers vs. Red Sox odds have Detroit as -186 favorites (risk $186 to win $100), while the over/under for total runs is 8. 

Before making any Red Sox vs. Tigers picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times, and is coming off a 5-0 week on top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.   

The model has simulated Tigers vs. Red Sox 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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