Rams vs. 49ers odds, line: Proven model reveals NFL picks, predictions for Thursday Night Football matchup
The SportsLine Projection Model has simulated Los Angeles Rams vs. San Francisco 49ers 10,000 times and revealed its Week 15 NFL picks
The Los Angeles Rams and San Francisco 49ers will meet in a key NFC West matchup on Thursday Night Football. Los Angeles, which beat San Francisco 27-24 in Week 3, will try to sweep the season series with the 49ers for the first time since 2018. The Rams (7-6), second in the NFC West, are coming off a 44-42 win over the Buffalo Bills. The 49ers (6-7), tied for third in the division with the Arizona Cardinals, downed the Chicago Bears, 38-13, last Sunday.
