Pistons vs. Knicks odds, line: Proven model reveals picks for NBA first-round matchup on April 21, 2025

The third-seeded New York Knicks look to take a commanding 2-0 series lead when they battle the sixth-seeded Detroit Pistons in Game 2 of their Eastern Conference first-round matchup on Monday. The Pistons (44-38), who placed fourth in the Central Division, are 22-20 on the road so far this season. The Knicks (51-31), who were second in the Atlantic Division, are 28-14 at home in 2024-25. Isaiah Stewart (knee) is questionable for Detroit, while New York has no injuries to report.

Tip-off from Madison Square Garden in New York is set for 7:30 p.m. ET. The teams have split their 16 all-time postseason meetings. The Knicks are 7-point favorites in the latest Pistons vs. Knicks odds, while the over/under for total points scored is 221. New York is at -271 on the money line (risk $271 to win $100), while Detroit is at +219 (risk $100 to win $219).

Before making any Pistons vs. Knicks picks, check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters the first full week of the 2025 NBA playoffs on a sizzling 156-116 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It is also 22-11 (67%) on top-rated NBA against-the-spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Pistons vs. Knicks 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits well over 50% of the time!

Who wins Pistons vs. Knicks, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 156-116 roll on top-rated NBA picks!