Pistons vs. Cavaliers odds, line: Proven model reveals picks for NBA Eastern Conference semifinal Game 6 matchup on Friday, May 15

The fourth-seeded Cleveland Cavaliers will look to close out their best-of-seven series when they face the one-seeded Detroit Pistons in Game 6 of their Eastern Conference semifinal on Friday night. Cleveland beat the Pistons 117-113 on Wednesday in Game 5 of the series to take a 3-2 series lead. 

Tipoff from Rocket Arena in Cleveland is set for 7 p.m. ET. The Cavaliers are a 4.5-point favorite in the latest Pistons vs. Cavaliers odds from FanDuel Sportsbook, while the over/under for total points scored is 210.5. 

Before making any Pistons vs. Cavaliers picks, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second round of the 2026 NBA playoffs on a sizzling 26-9 roll (74%) on top-rated NBA spread picks this season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen HUGE returns!

The model has simulated Pistons vs. Cavaliers 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread hits more than 50% of the time!

Who wins Pistons vs. Cavaliers, and which side of the spread hits more than 50% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 26-9 roll on top-rated NBA picks!