The Pittsburgh Pirates and Chicago Cubs open a three-game series on Friday afternoon in a key NL Central Division matchup. First pitch is at 2:20 p.m. ET at Wrigley Field in Chicago. William Hill Sportsbook lists Chicago as the -140 favorite (risk $140 to win $100) in the latest Pirates vs. Cubs odds. The Over-Under for total runs is set at 7.5 (see the latest lines for every game on our MLB odds page).

Before making any Pirates vs. Cubs picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a profitable start in 2021, going 36-28 on top-rated MLB money-line picks through five weeks, returning almost $400. Anyone following it has seen HUGE rewards! 

Now, it has set its sights on Pirates vs. Cubs. We can tell you it's leaning Over, but it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Pirates vs. Cubs? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the Pirates vs. Cubs money line you should be all over on Friday, all from the model that was up over $1,400 on MLB picks in 2019!