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Patriots vs. Colts game line, odds: NFL picks, predictions for Saturday night's game from proven computer model

The SportsLine Projection Model has simulated the Patriots vs. Colts matchup 10,000 times and revealed its Week 15 NFL picks
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The New England Patriots (9-4) go for their eighth straight win on Saturday night when they visit the Indianapolis Colts (7-6) for an NFL Week 15 showdown at Lucas Oil Stadium.

Kickoff is set for 8:20 p.m. ET. The Colts are 2.5-point favorites in the latest Patriots vs. Colts odds from Caesars Sportsbook, while the Over-Under for total points is 46. Before you make any Colts vs. Patriots picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 15 of the 2021 season on an incredible 132-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model has considered that Indy's No. 2 rushing game (151.7 yards per game) could do damage against a Patriots defense that ranks 19th against the run (114.5). Running back Jonathan Taylor leads the NFL with 1,348 yards and also has 336 receiving yards, with 18 total TDs. Quarterback Carson Wentz has 22 TD passes and just five interceptions while throwing for 2,948 yards. Defensively, the Colts are in the top 15 in total yards (342.1 per game) and passing yards (230.2) while allowing fewer than 22 points per game (ninth).

The model also has taken into account that New England's defense has been playing at a very high level. The unit has forced 26 turnovers, with J.C. Jackson leading the way with seven interceptions, and allows an NFL-low 15.4 points per game. It also should be able to get after Wentz, with Matthew Judon (12.5 sacks) leading a pass rush that has taken quarterbacks down 32 times. The offense led by steady rookie quarterback Mac Jones is in the top 10 in rushing (123.5 yards per game) and scoring (26.9 points).

Now, the model has broken down Patriots vs. Colts and revealed its results. We can tell you it's leaning Under the total, and it also says one side of the spread has ALL the value! You ABSOLUTELY need to see it before locking in any Patriots vs. Colts picks of your own.

So who wins Colts vs. Patriots on Saturday night? And which side of the spread has ALL the value? ... Join SportsLine right now to see which side of the Patriots vs. Colts spread to back, all from the dialed-in NFL model that's up almost $7,000 on top-rated picks!

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SportsLine Staff