The rubber match of a three-game series is on tap for Wednesday as the San Diego Padres visit the Pittsburgh Pirates. San Diego (5-6) won Monday's contest, which was its third win a row. However, Pittsburgh (7-4) ended that win streak by taking Tuesday's matchup to give the team five victories over its last six games. Michael King (0-1, 3.38 ERA) will make his third start for the Padres, and he'll be opposed by Mitch Keller (1-0, 1.50 ERA) as he also takes the mound for the third time in the 2026 MLB season.
First pitch is at 12:35 p.m. ET from PNC Park in Pittsburgh. The latest Pirates vs. Padres odds list Pittsburgh as the -113 favorite on the money line (risk $113 to win $100). The over/under for total runs is 7.5.