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Padres vs. Mariners odds, line, prediction: Proven MLB model reveals Sunday Night Baseball picks for May 17

SportsLine's projection model, which is on a 7-1 run on all top-rated MLB picks, has locked in its 'Sunday Night Baseball' predictions for the San Diego Padres vs. Seattle Mariners

ByUpdated: May 17, 2026 3:02AM UTC . 2 min read

An interleague matchup on MLB Rivalry Weekend has the Seattle Mariners hosting the San Diego Padres on 'Sunday Night Baseball'. Seattle (22-25) has dropped the first two games of this series, including a 7-4 defeat on Saturday. San Diego (27-18) is seeking its first three-game winning streak since April 18-21. George Kirby (5-2, 2.84 ERA) will take the ball for the Mariners, countered by Lucas Giolito, who will make his first appearance of the season.

First pitch is at 7:20 p.m. ET from T-Mobile Park in Seattle. The latest Mariners vs. Padres odds list Seattle as the -162 favorite on the money line (risk $162 to win $100). The over/under for total runs is 7.5.

Before making any Padres vs. Mariners picks or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times, and enters Week 8 on a 7-1 run on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns!

The model has simulated Mariners vs. Padres 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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Ross Kelly
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