Orioles vs. Red Sox odds, line, prediction: 2026 MLB picks for Thursday, June 4 from proven model

The Baltimore Orioles and Boston Red Sox continue their series when they meet on Thursday's MLB schedule at Fenway Park. The Orioles (29-33) are fourth in the AL East, just one spot ahead of Boston. The Red Sox (26-34) are last in the AL East, two games behind Baltimore, have lost four of their last six at home. Trevor Rogers (2-6, 6.84 ERA) takes the ball for Baltimore, countered by Boston RHP Brayan Bello (2-5, 5.63 ERA).

First pitch is set for 1:35 p.m. ET from Fenway Park in Boston. The Red Sox are -120 favorites on the money line (risk $120 to win $100) in the latest Orioles vs. Red Sox odds, with Baltimore priced as the -100 underdogs. The over/under for total runs is 10.5, tying it for the highest of Thursday's MLB slate.

Before making any Orioles vs. Red Sox picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

SportsLine Projection Model simulates every MLB game 10,000 times and enters Week 11 of the MLB season on a red-hot 17-5 run (77%) on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has simulated Orioles vs. Red Sox 10,000 times and the results are in. The model is going Under on the total, and is also says one side of the money line has ALL the value!

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