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The No. 6 Oregon Ducks arrive at Boone Pickens Stadium on Saturday having opened their campaign by holding off Boise State in a 34-27 win in which quarterback Dante Moore threw for 378 yards and three touchdowns. The Oklahoma State Cowboys, meanwhile, are coming off a troubling 24-10 loss at Tulsa in Week 1 as first-year head coach Eric Morris and new starting quarterback Drew Mestemaker look to find their footing in what promises to be a difficult rebuild. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Kickoff is set for noon ET at Boone Pickens Stadium in Stillwater, Oklahoma. The Ducks are 23.5-point favorites in the latest Oregon vs. Oklahoma State odds, while the over/under is 55.5 points.
Before making any Oregon vs Oklahoma State picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is on a 33-20 run on top-rated college football money-line picks since the 2024 season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
The model has simulated Oregon vs Oklahoma State 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits more than 60% of the time!
So who wins Oregon vs Oklahoma State, and which side of the spread hits more than 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 33-20 run on top-rated CFB picks!
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