Teams looking to start the season 2-0 meet when the Oklahoma State Cowboys take on the sixth-ranked Oregon Ducks in a Week 2 college football non-conference matchup on Saturday on CBS and Paramount+. The Cowboys, who were 3-9 overall and 0-9 in the Big 12 last season, were 1-5 on the road in 2024. The Ducks, who were 13-1 a year ago, are 20-1 on their home field over the past three-plus seasons.

Kickoff from Autzen Stadium in Eugene, Ore., is at 3:30 p.m. ET. Oregon won the only previous meeting with Oklahoma State, earning a 42-31 win in 2008. The Ducks are 28.5-point favorites in the latest Oklahoma State vs. Oregon odds, while the over/under for total points scored is 57.5 via SportsLine consensus.

Before making any Oklahoma State vs. Oregon picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

Be sure to watch this game on CBS and Paramount+, where new users can get a free one-week trial. Sign up here.    

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and  was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Oklahoma State vs. Oregon 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Oklahoma State vs. Oregon, and which side of the spread hits in well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!