Teams coming off narrow Week 1 wins clash when the Ohio Bobcats battle the Penn State Nittany Lions on Saturday. Penn State leads the all-time series 5-1, although Ohio pulled out a 24-14 win in their last meeting in 2012. Kickoff from Beaver Stadium at University Park, Pa., is set for noon ET. Penn State is favored by 27.5 points at Caesars Sportsbook, while the over/under is set at 54 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Ohio vs. Penn State picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

The model knows the Nittany Lions will be led by fifth-year senior quarterback Sean Clifford. Clifford was solid in the season opener at Purdue, completing 20 of 37 passes (54.1%) for 282 yards and four touchdowns. He was picked off once. Clifford is coming off a season in which he threw for 3,107 yards and 21 TDs against eight interceptions. For his career, he has completed 627 of 1,042 throws (60.2%) for 8,121 yards and 66 touchdowns. He has been picked off 25 times.

The model also knows the Bobcats have an experienced quarterback in redshirt junior Kurtis Rourke. Last week against Florida Atlantic, Rourke was sharp, completing 27 of 34 passes (79.4%) for 345 yards and four scores. He also rushed for another touchdown. In three-plus seasons at Ohio, Rourke has been an accurate passer, completing 228 of 339 passes (67.3%) for 2,548 yards and 18 touchdowns against seven interceptions.

Now, it has set its sights on Ohio vs. Penn State. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in almost 70% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

So who wins Ohio vs. Penn State? And which side of the spread hits in almost 70% of simulations? Join SportsLine now to find out, all from the model that has crushed its top-rated college football picks against the spread!