The first-ever national title in the 12-team College Football Playoff era is up for grabs as the No. 8 seed Ohio State Buckeyes take on the No. 7 seed Notre Dame Fighting Irish on Monday in the 2025 College Football National Championship game. Ohio State (13-2) has rolled past Tennessee, Oregon and Texas to advance to the title game, while Notre Dame (14-1) has defeated Indiana, Georgia and Penn State. The Buckeyes are 6-2 against the spread in their last eight games when playing as the favorite, while Notre Dame is 7-0-1 ATS in its past eight meetings against an opponent from the Big Ten. 

Kickoff from Mercedes-Benz Stadium in Atlanta is set for 7:30 p.m. ET. The Buckeyes are 8.5-point favorites in the latest Ohio State vs. Notre Dame odds via SportsLine consensus, while the over/under for total points scored is 45.5. Ohio State is the -418 money-line favorite (risk $418 to win $100), while Notre Dame is the +323 (risk $100 to win $323) underdog. 

Before entering any Notre Dame vs. Ohio State picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks. It went 43-36 on top-rated college football picks in the 2024 season, and was a profitable 27-16 combined on money-line and over/under picks. It also called eight of the 10 outright winners in the College Football Playoff bracket thus far. Anyone following could have seen STRONG returns!

The model has simulated Ohio State vs. Notre Dame 10,000 times and the results are in. The model is leaning Over the total, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Notre Dame vs. Ohio State, and which side of the spread hits in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has called eight outright winners in the College Football Playoff!

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