The No. 21 Notre Dame Fighting Irish take on the No. 19 South Carolina Gamecocks in the 2022 TaxSlayer Gator Bowl at 3:30 p.m. ET on Friday. Notre Dame is favored by 4.5 points at Caesars Sportsbook, while the over/under is set at 51 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Notre Dame vs. South Carolina picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Notre Dame has the superior defense in this matchup. The Fighting Irish are allowing only 21.8 points and 327.1 total yards per game. Notre Dame is also giving up fewer than 200 passing yards per game, including a 58.1% completion rate and 6.6 yards allowed per attempt. The model also knows South Carolina has a prolific passing attack, averaging almost 260 yards per game. The Gamecocks average 8.3 yards per pass attempt, and wide receiver Antwane Wells Jr. ranks No. 2 in the SEC in receptions and receiving yards.

Now, it has set its sights on Notre Dame vs. South Carolina. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Notre Dame vs. South Carolina? And which side of the spread hits in well over 50% of simulations? ... Join SportsLine right now to find out which side of the Notre Dame vs. South Carolina spread you should be all over Friday, all from the model on a roll on college football picks!