We've got another exciting ACC matchup on the schedule as the Notre Dame Fighting Irish and Louisville Cardinals are set to tip at 8 p.m. ET on Sunday at Purcell Pavilion at the Joyce Center. Notre Dame is 11-13 overall and 8-3 at home, while Louisville is 19-6 overall and 7-2 on the road. Louisville is favored by 7.5 points in the latest Notre Dame vs. Louisville odds, and the over/under is 145.5 points.

Before entering any Louisville vs. Notre Dame picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 15 of the 2024-25 season on a 211-154 betting roll (+2024) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has simulated Notre Dame vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that hits in almost 80% of simulations. 

So who wins Notre Dame vs. Louisville? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.