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No. 2 Ohio State vs. No. 5 Michigan college football odds, picks: Advanced computer model reveals picks for Saturday's Big Ten clash

The SportsLine Projection Model, which is up almost $3,700 over the past five-plus years, has simulated the conference battle between the Buckeyes and Wolverines 10,000 times
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The No. 2 Ohio State Buckeyes (10-1, 8-0) look to post their ninth consecutive victory in the series between the Big Ten Conference rivals when they visit the fifth-ranked Michigan Wolverines (10-1, 7-1) for the 117th edition of "The Game" on Saturday. Kickoff from Michigan Stadium in Ann Arbor is scheduled for noon ET.

The Buckeyes are seven-point favorites in the latest Ohio State vs. Michigan odds from Caesars Sportsbook, while the over-under for total points scored is 64.5. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you consider your Michigan vs. Ohio State picks or college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The model knows Ohio State possesses the most potent offense in the nation, ranking first in both yardage (559.5) and scoring (47.2 points). The Buckeyes have produced at least 40 points in eight of their 11 games this season and 50 or more on six occasions. Redshirt freshman quarterback C.J. Stroud, a contender for the Heisman Trophy, threw for 432 yards in Ohio State's 56-7 destruction of Michigan State last week and tied the school record with six touchdown passes.

The model also knows Michigan has one of the top defenses in the country as it is 10th in total defense (306.8 yards), eighth against the pass (178.4) and seventh in points allowed (16.3). The Wolverines' ground attack is led by senior running back Hassan Haskins, who has rushed for 1,063 yards and is tied for 16th nationally with 13 touchdown runs. Sophomore Blake Corum, who has recorded 778 yards and 10 TDs on the ground, hopes to return to action after missing Michigan's last two games with a high-ankle sprain.

Now the model has simulated Ohio State vs. Michigan 10,000 times, and the results are in. We can tell you that the model is leaning Over on the total, and it also says one side of the spread hits 60 percent of the time. You ABSOLUTELY need to see it before locking in your own picks.

Who wins the Ohio State vs. Michigan matchup in Saturday's Big Ten showdownAnd which side of the spread hits 60 percent of the time? ... Join SportsLine right now to see which side of the Michigan vs. Ohio State spread you need to jump on Saturday, all from the computer model on a 39-25 run on its top-rated college football side picks!

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SportsLine Staff