The San Francisco 49ers will take on NFC West rivals the Arizona Cardinals on Monday Night Football at Estadio Azteca in Mexico City. This will be the second matchup between the teams in Mexico, which has hosted four NFL regular-season games. The first meeting, billed as "Fútbol Americano," was the first NFL regular-season game outside the United States, and the Cardinals defeated the 49ers 31-14.

Kickoff is set for 8:15 p.m. ET. San Francisco is a 10-point favorite in the latest 49ers vs. Cardinals odds from Caesars Sportsbook, and the Over/Under for total points scored is 43. Before you make any Cardinals vs. 49ers picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 11 of the 2022 NFL season on an incredible 153-108 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows the 49ers have won two in a row and have talent all over the field. They also are expected to have significant backing in Mexico City. Quarterback Jimmy Garoppolo has been managing games and avoiding mistakes, getting the ball to players like running back Christian McCaffrey, tight end George Kittle and receiver Deebo Samuel. McCaffrey has 226 total yards and four TDs during the two-game win streak. The San Francisco defense ranks first in the league in allowing just 281 total yards per game.

The model also has considered that Arizona swept the 49ers last year and comes in off a 27-17 victory against the Rams as a 3.5-point road underdog. Receiver Deandre Hopkins has 396 receiving yards since returning from injury in Week 7. The Cardinals' defense is ninth in the league against the run (110 yards per game), so they should make Garoppolo beat them.

Now, the model has set its sights on Cardinals vs. 49ers on Monday Night Football. We can tell you the model is leaning Under the total, and one side of the spread cashes in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

So who wins 49ers vs. Cardinals on Monday Night Football? And which side of the spread cashes well over 50 percent of the time? Join SportsLine now to see which side of the Cardinals vs. 49ers spread to back, all from the model that's an amazing 153-108 on NFL picks!