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All four of the Jets home games have been decided by either 3 points or 5 points, as NFL betting trends like these could assist in winning a Week 10 NFL score prediction. New York will host a Bills team off a Monday win over Minnesota, and Buffalo just happened to have a 3-point game in its last contest following a MNF matchup in Week 6. Not only that, but two of the last four times the Bills visited the Jets, the point differential was 3 points. Pinpointing a scoring margin is one of the first steps in hitting on a Week 10 NFL correct score pick. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code SPORTSLINE55:

Once you have the margin of victory, then your NFL bet on an exact score needs to decide which team wins and how much they score. The Bills being 10-2 over the last 12 meetings with the Jets could certainly influence the former. An NFL exact score prediction could return up to +18000, so the high risk is justified with a high reward.

SportsLine expert Eric Cohen has made his exact Week 10 NFL score predictions for every matchup. Before you lock in any NFL picks, make sure you see what Cohen has to say.

A SportsLine expert and host, Cohen is evaluating the entire Week 10 NFL slate and delivers score predictions and logic for each matchup. Last season, Cohen went 188-96-1 (66%) on straight-up NFL picks and is 84-51-1 (62%) in the 2026 NFL season and went 14-1 with his Week 9 picks!

We can tell you that Cohen likes the Jaguars (-10.5, 46.5) to defeat Tennessee on the road. The Titans do remain within the spread at this margin, while the Under hits with several points to spare. "Could Jacksonville be the team to beat in the AFC? They certainly are acting like it, having made significant additions via the trade market on defense this week. In the Jaguars four-game winning streak over their division rivals, Tennessee has only scored a combined 29 points in those games. Coming off a bye week, expect a slightly better performance from the Titans offense, but I'm not sure the defense will be able to adequately slow Trevor Lawrence and company." Jaguars 27, TITANS 17

In addition, Cohen has identified FIVE games where he projects the total to be at least a touchdown off from the listed over/under, potentially providing a huge payday with the alternate lines! Nailing these results is key to making profitable Week 10 NFL picks!

Who wins every Week 10 NFL game, and which five picks should you lock in now? ... Join SportsLine now to get Eric Cohen's Week 10 NFL score predictions and find out today!

Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.

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