Two sets of division leaders clash to headline the NFL Week 10 schedule. On Sunday, the AFC East-leading New England Patriots, led by quarterback Drake Maye, battle the NFC South-leading Tampa Bay Buccaneers and quarterback Baker Mayfield. On 'Monday Night Football,' Jalen Hurts leads the Philadelphia Eagles into Lambeau Field to face Jordan Love and the Green Bay Packers. Both Tampa Bay and Green Bay enter as 1.5-point favorites.

Another matchup involving contenders sees the Los Angeles Rams (6-2) traveling to San Francisco to face the 49ers (6-3) in a key NFC West matchup. The Rams are 5-point favorites even though the Niners boast a 10-4 record versus Los Angeles since 2019. The largest spread is Buffalo at Miami (+9.5). The slimmest spread sees Jacksonville (-1) as a road favorite over Houston as the Texans will be without C.J. Stroud (concussion), with Jacksonville missing Brian Thomas Jr. (ankle).

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Before making any Week 10 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Week 10, the AI says the Bills (-9) cover comfortably against the Dolphins, who may be on their way to a rebuild. Josh Allen leads the Buffalo offense, completing 70.4% of his passes for 1,833 yards and 13 touchdowns with four interceptions. He has also rushed 55 times for 280 yards (5.1 average) and seven touchdowns, including two in the 28-21 Week 9 win over the Kansas City Chiefs.

SportsLine AI rates the Bills as an A+ pick on the money line and also predicts a 36-22 win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 10! In fact, the AI has generated well over 20 HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 10 NFL bets.

Which NFL bets do you need to make NOW for Week 10? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2025 Week 10 NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!

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