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NFL Week 1 score predictions: Expert reveals game picks for the 2026 opening week

SportsLine expert Eric Cohen reveals his NFL score predictions for all 16 games in Week 1 of the 2026 NFL season

ByRoss KellyUpdated: Aug 31, 2026 8:18PM ET3 min read

As the 2026 NFL season approaches, bettors will race to sportsbooks to make NFL predictions on the spread, in addition to bets on the money line, total or with player props. However, another wager one could make is a Week 1 NFL score prediction, where you guess what the exact score will be for a given game. This is a high-risk, high-reward NFL bet and one that could produce a massive payout. Hitting on the exact score for the Chiefs vs. Broncos contest on Monday night could have a return of anywhere from +6000 to +15000.