Week 1 of the 2026 NFL preseason kicks off on Thursday with six games on the schedule. Two games kick at 7 p.m. ET, with Titans at 49ers wrapping the night up at 9 p.m. ET in the Tennessee debut for head coach Robert Salah, who was the defensive coordinator for the Niners last year. The latest NFL odds for preseason action on Thursday list the Titans at -2.5 on the road. Every line except for Bengals (-7) vs. Lions is 3 points or smaller. Bet the NFL at DraftKings, where new users get $150 in bonus bets instantly after $5+ in bets:

Before making any Week 1 NFL preseason picks for Thursday, you NEED to see the best bets from SportsLine NFL expert Larry Hartstein.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. He enters the 2026 NFL season on a 50-37-1 run on NFL spread picks, a 57.5% win rate. Anyone following has seen HUGE returns!

Now, Hartstein has locked in three confident best bets for Week 1 NFL preseason action on Thursday.

One of his picks: He's backing the Titans (-2.5) on the road against the Niners.

"The Titans' main backup quarterbacks, Mitchell Trubisky and Will Levis, both have plenty of NFL starting experience," he said. "Tennessee opened as the only road team favored Thursday for a reason."

Hartstein has locked in two other best bets, including backing an underdog he says has a big advantage at quarterback depth in its matchup!

So what are the best bets for Thursday's NFL preseason action, and what team has a HUGE edge at QB? ... Join SportsLine right now to see which teams to back, all from the expert who went 50-37-1 on his NFL picks in 2025!

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NFL preseason Week 1 NFL odds, best picks today: Back the Titans against the 49ers on Thursday

Larry Hartstein, who finished 2025 at 50-37-1 on NFL ATS picks, has locked in his best bets for Thursday's NFL preseason slate