Content on this page may include affiliate links. If you click and sign up/place a wager, we may receive compensation at no cost to you.
Divisional contests often result in slim NFL spreads, and that's the case when looking at the Week 10 NFL schedule. Half of the 14 games are divisional battles such as Packers vs. Vikings (+3), Panthers vs. Saints (+1.5) and Steelers vs. Bengals (-3.5). Elsewhere, Munich, Germany will host Patriots vs. Lions (-2.5), while Las Vegas will host Raiders vs. Seahawks. The latest Week 10 NFL odds have Seattle as 3-point road favorites as it plays its first ever regular season game in Sin City. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code SPORTSLINE55:
If you prefer making Week 10 NFL picks on totals, then the highest of the season will be on this Sunday's slate. Cowboys vs. 49ers has an O/U of 55.5 as each of Dallas' last three games have averaged 57.3 combined points. The lowest total is 38.5 in Ravens vs. Chargers on Monday night.
Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 10 of the 2026 NFL season on a 62-52 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has evaluated the latest NFL odds, simulated every snap for Week 10 of the 2025 NFL season, and the results are in.
We can tell you one of the model's strongest Week 10 NFL picks is that the Bills (-7.5, 50.5) cover at the Jets almost 60% of the time, with the Over hitting in almost 60% of simulations. Another one of its Week 10 NFL predictions: the Texans (-4.5, 39.5) cover at the Browns at 1 p.m. ET. Houston is forecasted to cover the spread in over 50% of simulations.
The model has also made the call on who wins and covers in every other NFL game this week and identified FOUR teams that cover in 65% of sims or more, potentially giving you a huge payday! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!
So which NFL teams should you back in Week 10, and which four picks should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 62-52 roll on top-rated NFL picks!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!
Written by Ross Kelly
View expert profile
