We've just reached the Week 6 NFL schedule, and the Chiefs are already having their fourth primetime game. They'll host the Lions on Sunday night in a potential Super Bowl preview that has Kansas City favored by 2.5 points, per the latest Week 6 NFL odds. We're also treated to our third two-game Monday Night Football slate of the 2025 NFL season with Bills vs. Falcons (+4.5) and then Bears vs. Commanders (-4.5). Thus, three quarterbacks from the 2024 draft class -- Caleb Williams, Jayden Daniels and Michael Penix Jr. -- plus last year's MVP in Josh Allen could be heavily involved in Week 6 NFL picks for MNF.
No team has a perfect spread record entering the Week 6 NFL schedule, and no team is winless versus the line. That spread parity could make it a bit more difficult to making NFL predictions, and, for the most part, there are mostly slim Week 6 NFL spreads.
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There are just two Sunday afternoon games with a line of more than a touchdown, including Rams vs. Ravens (+7), with Lamar Jackson ruled out. The widest spread is 14.5 points which is what the Packers are giving to the Bengals. Cincy will start the recently traded for Joe Flacco at quarterback, but his arrival hasn't shifted the line, which is the biggest of the 2025 NFL season.
Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has evaluated the latest NFL odds, simulated every snap for Week 6 of the 2025 NFL season, and the results are in.
We can tell you one of the model's strongest Week 6 NFL picks is that the Cowboys (-3.5, 48.5) cover the spread versus the Panthers in a Sunday 1 p.m. ET kickoff. The model has Dallas prevailing versus the spread well over 50% of the time. Another one of its Week 6 NFL predictions: the Buccaneers (-3, 46.5) cover versus San Francisco in almost 60% of simulations. The model also says the Over hits well over 50% of the time.
The model has also made the call on who wins and covers in every other NFL game this week and just revealed FIVE teams that win by double-digits! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!
So which NFL teams should you back in Week 6, and which five teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 39-20 roll on top-rated NFL picks!
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Written by Ross Kelly
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