NBA odds, lines, spreads, picks, predictions for Wednesday, April 29: 3-way parlay pays nearly +600

Three NBA first-round matchups highlight Wednesday's playoff schedule, including five Game 5 contests. In the Eastern Conference, the Pistons are 9.5-point favorites vs. the Magic at 7 p.m. ET, while the Cavaliers are 8.5-point favorites over the Raptors at 7:30 p.m. ET. In the West, the Lakers are 4.5-point favorites over the Rockets at 10 p.m. ET.

Before locking in any NBA bets or parlays, make sure you see what SportsLine's advanced computer model has to say. 

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second full week of the 2026 NBA playoffs on a sizzling 25-9 roll (74%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has evaluated the Wednesday NBA odds and locked in three confident NBA best bets. If you successfully parlay them you'd be looking at a big payout of nearly +600.

One pick we'll give away: The model is backing the Pistons to cover the 9.5-point spread against the Magic.

The model has also locked in two more strong picks, including an Over/Under pick that hits in over 60% of simulations! You ABSOLUTELY need to see it right now.

So what are the NBA best bets for Wednesday? ... Join SportsLine now to see who wins and covers every single NBA game this week, all from the model that's on a 25-9 run on top-rated NBA picks!