NBA odds, lines, spreads, picks, predictions for Wednesday, April 22: 3-way parlay pays over +550

Two NBA first-round playoff games highlight Wednesday's schedule. In the Eastern Conference, the Pistons are 8.5-point favorites vs. the Magic in the 7 p.m. ET matchup. In the West, the Thunder are 17.5-point favorites over the Suns at 9:30 p.m. ET.

Before locking in any NBA bets or parlays, make sure you see what SportsLine's advanced computer model has to say. 

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the first full week of the 2026 NBA playoffs on a sizzling 24-9 roll (73%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has evaluated the Wednesday NBA odds and locked in three confident NBA best bets. If you successfully parlay them you'd be looking at a big payout of over +550.

One pick we'll give away: The model is backing the Suns to cover the 17.5-point spread against the Thunder.

The model has also locked in two more strong picks, including an over/under play that hits nearly 70% of the time! You ABSOLUTELY need to see it right now.

So what are the NBA best bets for Wednesday? ... Join SportsLine now to see who wins and covers every single NBA game this week, all from the model that's on a 24-9 run on top-rated NBA picks!